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Binary clinical outcomes, including acute kidney injury, severe hypoglycemia, adverse events leading to treatment discontinuation, and cardiovascular events, were summarized descriptively without formal hypothesis testing, given the absence of a comparator group and limited statistical power

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They engage different receptor systems (amylin/GLP-1 versus GLP-1/GIP/glucagon) through different designs (blend versus single molecule)

For example, some gut microbes produce short-chain fatty acids that have been shown to stimulate GLP-1 secretion in the gut