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Demyelination was induced in C57Bl/6 mice by cuprizone (400 mg/kg/day p.o.) for 5 weeks

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Modeling finds marked early weight loss with tirzepatide that later plateaus as appetite returns and energy expenditure decreases, and discontinuation of the drug is linked to partial weight regain.
They are primarily used in the management of type 2 diabetes (T2D).
