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Timeline 2: One-week washout Day 0: Last Wegovy injection Day 7-14: No injection (washout week) Day 14: First Zepbound injection Day 21: Second Zepbound injection Weeks 6, 10, 14, etc.: Dose increases per titration schedule The washout approach lets semaglutide levels drop before introducing tirzepatide

Its one small shift that can affect mood, sleep, and metabolism all at once

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Zhong J, Maiseyeu A, Rajagopalan S

They still need to do the foundational part of the treatment of obesity, which is changing their lifestyle, she added

(2022) 23(5):e13428
