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Role repositioning: the appropriate clinical role of GLP-1RAs is not to replace ovulation induction or ART, but to serve as a periconception metabolic optimization tool

First, they swapped out the exact amino acid that DPP-4 targets for cleavage replacing it with a variant the enzyme simply cannot recognize

GLP-1 receptor agonists mimic or enhance the action of glucagon-like peptide-1, an incretin hormone involved in post-meal glucose control, insulin secretion, glucagon suppression, gastric emptying, appetite, and satiety

62 Another study that evaluated clinical outcomes in patients with diabetes, treated by cardiac resynchronization therapy with a defibrillator (CRT-d), and glucagon-like peptide 1 receptor agonists (GLP-1 RA) in addition to conventional hypoglycemic therapy versus CRTd patients under conventional hypoglycemic drugs found that CRTd patients with diabetes treated by GLP-1 RA therapy versus CRTd patients with diabetes that did not receive GLP-1 RA therapy, experienced a significant reduction of NYHA class, associated to higher values of 6 minutes walking, and higher rate of CRTd responders

Individuals should be counseled to avoid refined carbohydrates (i.e., refined grains, flour, starches, sugars), sugarsweetened beverages, red and processed meats, and most fast foods, ultraprocessed sweets, and savory snacks (Table 6)
Simon emphasizes that the story doesnt end there
