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The magnitude and pace of weight reduction observed in this patient occurred during active pharmacologic dose escalation and exceeded the minimum guideline-recommended threshold for clinically meaningful weight loss

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Some research links it to reductions in visceral fat

While many media reports tout the remarkable effectiveness of GLP-1 drugs (and their great expense) for weight loss, few address the serious side effects associated with their use, such as loss of skeletal muscle (and the risk of sarcopenia) and bone mineral density (and the risk of osteomalacia and osteoporosis), and the weight gain that typically follows their discontinuation