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Semaglutide targets a single GLP-1 receptor pathway, while Tirzepatide activates both GIP and GLP-1 receptors for broader metabolic impact

Common symptoms include dizziness, lightheadedness, blurred vision, fatigue, nausea, difficulty concentrating, and in severe cases, syncope (fainting)

Of note, there was also an increased rate of amputation noted for unknown mechanisms [23]

Russell, M.A., Wilson, C., Patel, U.A., Feyerabend, C

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Things like nausea, abdominal pain, constipation, or diarrhea