reduce insulin dose when starting glp-1 receptor agonist Glucagon-like peptide-1 receptor: mechanisms and advances in therapy GLP-1 receptor agonists are transforming

Notably, whereas Gcg is robustly expressed in -cells, its expression is suppressed in -cells through binding of pancreatic and duodenal homeobox 1 (Pdx1), Pax4, and homeobox protein Nkx6.1 to the G1 element, thereby competitively preventing the binding of Pax6/Maf heterodimers to the G1 element (Figure 2) [100,139,140]

doi: 10.1038/24884

The demand for GLP1-RA approved for obesity is high so there have even been supply shortages in Europe

GLP-1 secretion itself is stimulated in response to food intake (79)

The current evidence is promising but incomplete

[DOI] [PubMed] [Google Scholar] 873.Driessen J.H., Henry R.M., van Onzenoort H.A., Lalmohamed A., Burden A.M., Prieto-Alhambra D