glp-1 receptor agonist with dpp-4 inhibitor combination not recommended The Role of Inhibitors in the Treatment Algorithm of Type 2 Diabetes Mellitus: When to Select, What to Expect DPP4 Inhibitor Mechanism of Action
Description
Dulaglutide also deserves mention for its renal protective effects
Liraglutide attenuates myocardial fibrosis via inhibition of AT1R-Mediated ROS production in hypertensive mice
Weight loss on these drugs can be significant
Graphical Abstract Highlights 1
Clinical studies such as the GetGoal trial program demonstrated that while it improved glycemic control, its effect on body weight was small (typically 23 kg reduction) and not sufficient to warrant an obesity indication
doi: 10.1111/dom.13487
