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Activation of GLP-1R induces an increase in intracellular Ca 2+ in 40% of NTS astrocytes, while selective inhibition of astrocyte function in NTS abolishes exendin-4-induced inhibition of food intake (Reiner et al., 2016)

Baggio et al., Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans, Nat

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[DOI] [PubMed] [Google Scholar] 49.Rosenstock J., Wysham C., Fras J.P., Kaneko S., Lee C.J., Fernndez Land L., Mao H., Cui X., Karanikas C.A., Thieu V.T

This is why the STEP trial protocol includes two intermediate doses (1.7 mg) before reaching 2.4 mg, and why many people find their sweet spot below maximum