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29 Inconsistent findings in other species (mice) render the generality of these findings unclear

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Medical Dialogues / DCGI Approval Notice CDSCO Approved BMI Thresholds DCGI has approved semaglutide for obesity in adults with BMI 30 kg/m, or BMI 27 kg/m with at least one weight-related comorbidity (hypertension, T2D, dyslipidaemia, or sleep apnea)

Mean change in HbA1c to end of treatment according to baseline eGFR (truncated between 5th and 95th percentile) in SUSTAIN 46, and 10, and PIONEER 5 and 6

Moon et al., 2015), demonstrating the essential function of this residue in GLP-1R binding