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Description
They happen when medication is

Oral semaglutide delivered meaningful reductions in HbA1c and body weight among GLP-1RA-nave adults with type 2 diabetes in a Dutch real-world cohort
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Why it Matters
However, the insulinotropic effect of incretins is diminished in type 2 diabetic patients, due in part to reduced expression of incretin receptors as a consequence of glucotoxicity