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In conclusion, results of this study indicate the ability of liraglutide, with diet and exercise, to provide sustained weight loss over 2 years, greater efficacy compared to orlistat and improvements in many of the important obesity-associated metabolic and cardiovascular risk factors

Improve habits: Focus on protein-rich meals, strength training, and quality sleep to support weight loss

Pregnancy and breastfeeding considerations Tirzepatide is not recommended during pregnancy or breastfeeding, and the medication should be discontinued before planned conception

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The absence of a contraindication does not mean combination therapy is routinely recommended or well-studied

Clinical trials indicate promising results, with participants experiencing significant weight loss and improvements in body composition