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Blood Pressure Management Hypertension is a significant risk factor for stroke, especially in AFib patients

If fatigue persists beyond a week, reduce dose or frequency

Contact PlexusDx or your provider if you're unsure about timing to ensure safety

If you have upcoming surgery, knowing when to resume semaglutide after surgery is critical

Before starting or continuing both medications together, ensure you discuss: Your Complete Medical History: Previous or current mental health conditions, including depression, anxiety, bipolar disorder, or suicidal ideation History of seizures or conditions that lower seizure threshold Eating disorders (past or present) Cardiovascular disease, including hypertension Kidney or liver impairment Thyroid disorders Diabetes and current glycaemic control Gastrointestinal conditions, including pancreatitis or gallbladder disease Eligibility for Wegovy under NICE guidelines (typically requiring specialist weight management services, specific BMI thresholds, and other criteria) All Current Medications: Provide a complete list including: Prescription medications (especially anticoagulants like warfarin, antidiabetic drugs, or medications affecting seizure threshold such as tramadol, antipsychotics, tricyclic antidepressants, or quinolone antibiotics) Medications that affect CYP2B6 enzymes which metabolise bupropion Over-the-counter medicines Herbal supplements and vitamins Recreational substances or alcohol use Treatment Goals and Monitoring: Discuss realistic expectations for weight management and smoking cessation

Mood changes and worsening depression sometimes get dismissed as unrelated to a "diabetes or weight loss shot." But mental health changes are side effects worth watching, especially when they show up or get worse after starting treatment