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Mean (SD) [ 68 Ga]Ga-DO3A-Exendin-4 binding in pancreas uptake was decreased from SUV 55min 2.98 (0.74) at baseline to SUV 55min 1.46 (0.37) at a dose of 0.2 mg SAR425899 (Fig

95% CI, 0.27 to 0.92)

Furthermore, exendin-phe1 was the most efficacious insulin secretagogue when tested in parallel with extended incubations (Fig

doi: 10.1002/jcp.29204 87 BasalayMVDavidsonSMYellonDM

This permits once-daily dosing, which maintains adequate plasma concentrations over a 24-hour period [31]
Therefore, these results indicate that GLP-1R activation hinders fetal growth independently of fetal IGF-1, insulin, and glucose metabolism
