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Outcomes assessed at initiation, six months and discontinuation or last consultation included HS-PGA, flare frequency, Numerical Rating Scale (NRS) for pain and suppuration, Dermatology Life Quality Index (DLQI) and body mass index (BMI)
Individuals with T2DM taking tirzepatide, a dual GIP and GLP- 1 receptor agonist, experienced better weight loss and blood sugar control than patients taking GLP- 1 receptor agonism
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Variants in the GLP1R gene (such as rs6923761), GIPR gene (rs1800437), FTO gene (rs9939609), and MC4R gene (rs17782313) affect appetite regulation, satiety signaling, and metabolic rate
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