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Direct cortisol-lowering is not semaglutide's primary mechanism, but clinical observations suggest GLP-1 activation may normalize cortisol's diurnal rhythm and reduce stress-induced cortisol spikes

However, very few of them are approved for DNP management

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Rare cases of pulmonary hypertension have been reported with phentermine alone, though the absolute risk appears low

(Also, patients who are prescribed semaglutide have often not responded to other obesity or diabetes drugs