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Biological activity of the endocannabinoid system Once in the body, 9 -THC and CBD exert their effects via the endocannabinoid system (ECS).The identification of the specific binding sites for 9 -THC in the brain [45], complemented by the cloning of the cannabinoid receptor 1 (CB1), that led to the development of the concept of a cannabinoid receptor system given the binding of 9 -THC to CB1 as a partial agonist [46]

In parallel, cAMP activates the exchange protein directly activated by cAMP (EPAC), which regulates vesicle priming and exocytosis, thereby fine-tuning insulin release [17,18,19]

Patients with Tetralogy are at increased risk of both atrial and ventricular arrhythmias

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Some patients notice changes just a few weeks after initiating treatment, while for others it may take several months