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The regulation of energy homeostasis by centrally-produced GLP-1 is not yet fully understood

Since their inception in the commercial market in the mid-twentieth century, sulfonylureas (SUs) have remained a therapeutic option in the management of type 2 diabetes (T2D)

GLP-1 RAs have proven potent for the management of diabetes and have been linked toadditional cardiometabolic benefits!

Functional analyses demonstrated that i ) DIV-1 is required for the robust proliferation typical of the germline, ii ) loss of DIV-1 enhances and suppresses specific phenotypes that are associated with reduced and elevated GLP-1/Notch activity in germline and somatic tissues, and iii ) DIV-1 works together with FBF/PUF proteins, downstream regulators of GLP-1/Notch signaling, to promote germline stem cell (GSC) maintenance and germline proliferation

Diabetes is associated with cardiovascular (CV) disease, especially in patients with inadequate glycaemic control or high CV risk factors