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For example, Muayad et al compared 61,998 patients with diabetes using GLP-1 RAs with metformin users in the US Collaborative Network of the TriNetX EHR database to calculate the risk of developing ocular hypertension or primary open-angle glaucoma, requiring topical glaucoma medication, or requiring laser trabeculoplasty

At week 20, the change from baseline in HbA1c in patients treated with JANUVIA (N=95) was 0.06% compared to 0.23% in patients treated with placebo (N=95), a difference of -0.17% (95% CI: -0.62, 0.28)

By understanding future PBM disruptors, manufacturers can better prepare messaging around optimized cost predictability and patient outcomes

Ongoing research is needed to clarify optimal dosing strategies, appropriate duration of therapy, and long-term outcomes, including the potential for sustained ICP reduction to below 25 cmCSF, resolution of papilledema, and improvement in headache outcomes

UNDERSTANDING GIP (TIRZEPATIDE) GIP, or glucose-dependent insulinotropic polypeptide, is another natural gut hormone that plays a key role in metabolic regulation