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Certain pre-existing conditions like medullary thyroid carcinoma history may disqualify some patients from using semaglutide, requiring alternatives

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To compensate for this reduced absorption, oral semaglutide requires daily dosing and must be taken under strict conditions: on an empty stomach with no more than 4 ounces of plain water, with a mandatory 30-minute wait before consuming any food, beverages, or other oral medications