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Description
Metabolic Adaptation: As you lose weight, your metabolism slows downa process known as metabolic adaptation

S1 Flow diagram of included studies

This tapering period allows hunger cues to return gradually rather than flooding back suddenly

Therefore, we hypothesise that a combination of pancreatic GLP-1 and GIP is necessary for the full effect of DPP-4 inhibitors on glucose homeostasis

together they form the balanced, grounded stance that serves people best when a field is genuinely developing but not yet settled

Additionally, there is evidence of weight regain when people stop using Wegovy
