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For non-diabetic obesity, the cleanest comparison is between two separate trials: STEP 1 (semaglutide 2.4 mg, Wilding et al., NEJM 2021): 14.9% body weight loss at 68 weeks SURMOUNT-1 (tirzepatide 15 mg, Jastreboff et al., NEJM 2022): 20.9% body weight loss at 72 weeks A roughly 6 percentage point gap in average weight loss favors tirzepatide

Menstrual cycle changes have not been systematically studied or reported as primary or secondary endpoints in these trials

Mechanism of Action Blocks Angiotensin II type 1 (AT) receptors Effects: Vasoconstriction Aldosterone secretion Blood pressure Sodium & water retention Protects heart and kidneys It does not inhibit ACE, so no bradykinin buildup less cough and angioedema compared to ACE inhibitors

If you are taking semaglutide, your doctor will monitor you closely to ensure the medication is working safely

While semaglutide has proven effective for weight reduction, potential side effects like gastric bezoars warrant attention

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