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Challenges include variable ionization efficiency, difficult chromatographic separation, and complex fragmentation patterns
While effective, potential side effects include nausea and constipation

Both human and rodent studies demonstrate intestinal hypertrophy after RYGB 21 , with shifts in glucose metabolism towards pathways that support tissue growth 22

This is especially important for individuals with diabetes, autoimmune conditions, epilepsy, or those taking anticoagulants, immunosuppressants, or medications metabolised by the same liver enzymes as melatonin
