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doi: 10.1002/(ISSN)1097-0142 21 WilkeLGMcCallLMPostherKEWhitworthPWReintgenDSLeitchAMet al

Challenges include gastrointestinal side effects, nutritional deficiencies due to calorie reduction, muscle and bone loss, low long-term adherence with subsequent weight regain, and high costs, resulting in low cost-effectiveness

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