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Nausea is more common than constipation, especially during dose escalation

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Hauge-Evans AC, King AJ, Carmignac D, et al

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He maintained that while the benefits of off-label prescribing can be effective to treat targeted symptoms, one common question within the medical community keeps arising: Is it prudent to jump the line of FDA-approval and essentially bio-hack your way to better health before the science is fully clear? For example, by treating alcoholism with a drug that reduces a sense of reward, satisfaction, perhaps an aspect of joy, and, secondarily, cravings, are we perhaps taking a shortcut and denying the development of other unconscious or conscious processes like stress tolerance, anxiety tolerance, resilience, patience, balance and prudence? Dillon continued