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Also known as the Master Antioxidant, glutathione is one such naturally occurring molecule that has a critical role to play in ensuring cellular well-being

The peptide itself is identical

The reaction is catalyzed by a family of enzymes called Glutathione S-transferases (GSTs), which facilitate a nucleophilic attack, covalently binding the sulfur atom of glutathione directly to the toxic Phase I metabolite

In mosteukaryotic cells, GR maintains the ratio of [GSH]/[GSSG], and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis

doi: 10.1016/j.prmcm.2023.100222 53

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