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I have watched friends and acquaintances who take GLP1 agonists and lose weight speak about weight in ways that make me uncomfortable

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Nakazato M, Murakami N, Date Y, et al

Glucagon-like peptide 1 (GLP-1) is an incretin 30 amino-acid peptide hormone produced in hindbrain neurons and in specialized enteroendocrine cells (L cells) in the distal small and large intestines that is released after food intake [23, 24]

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In contrast, other effects, including modulation of mitochondrial and ER function, ceramide reduction, macrophage polarization, and suppression of hepatic inflammation via NKT cells, have been primarily demonstrated in preclinical models