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In the United States, a major health poll found that around 1 in 8 adults have used a GLP-1 medication , with approximately 6% currently taking one

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For example, the triple-receptor-agonist retatrutide is administered once weekly because of its extended half-life of 6 days [24]

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Other factors are the influence of diabetic cardiomyopathy (DM-induced cardiac remodeling resulting in diastolic and/or systolic dysfunction) [21], genetic and epigenetic modifications [22], and the possible adverse effect of hypoglycemic agents