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This population has been analyzed in detail by Lynch et al

Previous research has shown that GLP1 (936) can decrease levels of IL-1 , interleukin 6 (IL-6), and tumor necrosis factor- (TNF-)

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Moberly SP, Mather KJ, Berwick ZC, Owen MK, Goodwill AG, Casalini ED, Hutchins GD, Green MA, Ng Y, Considine RV, Perry KM, Chisholm RL, Tune JD: Impaired cardiometabolic responses to glucagon-like peptide 1 in obesity and type 2 diabetes mellitus

In contrast, daily bolus injections of TZP/Sema showed greater inter-animal variability, suggesting less consistent glycemic control