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Data were analyzed using an intention-to-treat rather than a per-protocol analysis (typically preferred for a noninferiority trial) because the protocol allowed for dose adjustment (3, 7, or 14 mg per day) and treatment pauses due to adverse events

fMRI study of problem-solving after severe traumatic brain injury

These extended studies will help confirm whether the favorable early safety signals persist over longer timeframes

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( b-c ) Representative histological images of mKate2-PDE4-cat expression (magenta) and DAPI (blue) from example 1 ( b