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For context, the Phase 2 study (Jastreboff 2023, NEJM) reported about 17.5 percent mean weight reduction at 24 weeks on 12 mg
Food and Drug Administration to put semaglutide and tirzepatide on a list of drugs that are too hard for compounding pharmacies to make

The fact that bupropion plays well with tirzepatide is a genuine advantage

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However, researchers in warmer climates should be aware that semaglutide arriving hot is a real concern during summer months

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