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However, there is also a possibility that some of the effect may be independent of GLP-1, because DPP-4 inhibition still reduced -cell apoptosis in human islets cultured in the presence of exendin 9-39 (99), suggesting that other mediators might be involved, but it was also suggested that an anti-inflammatory action could have played a role (99)

The active comparator, new user study design in pharmacoepidemiology: historical foundations and contemporary application

Two unique compounds have been evaluated in Phase 2 trials (SAR425899 and MEDI0382), and although dual-agonism has produced promising results on body weight and glycemic control in diabetic patients [926,927], it is not apparent that these co-agonists are superior to selective GLP-1R agonists

3 | Broader indications for GLP-1s could be coming

Having a pouch and wanting to reduce the frequency of bowel movements per day (for example) would not qualify a patient for a prescription according to the licensed indications

For many, it becomes a long-term recurring expense