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The MAP is intended to ensure that treatment is prioritised for those most likely to benefit and at highest clinical risk

doi: 10.1007/s00125-015-3727-0 39 XuFLinBZhengXChenZCaoHXuHet al

AD is frequently reported to be accompanied by decreased glucose transport across the BBB and 6 month treatment of AD patients with liraglutide improved BBB glucose transfer relative to placebo controls [837]

Dash S, Leiter LA

Overall, when administering GLP-1RA plus SGLT2i combination therapy, it is important to adopt an individualized approach to therapy taking into account individual preferences, costs and coverage, AE profile, consideration of kidney function and glucose-lowering efficacy, desire for weight loss, and comorbidities such as frailty [6, 22, 24]

To further explore such a possibility, a subsequent preclinical study was performed in insulin-deficient streptozotocin (STZ) diabetic rats with exendin-4 (57)