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GLP-RT is commonly used in laboratory research to investigate signaling between three metabolic hormone receptors: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR)

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In animal studies, GLP-1 agonists triggered anxiety early in treatment which then subsided and shifted toward reduced depression-like behaviour with continued use