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10.1002/tox.24070 67 WuZ.DengW.YeY.XuJ.HanD.ZhengY.et al (2024)

Digoxin has low solubility and low permeability

This impurity had not been previously identified or characterized

patients should report right upper quadrant pain, fever, or jaundice Diabetic retinopathy complications : Rapid glycemic improvement may temporarily worsen retinopathy in susceptible patients Acute kidney injury : Usually secondary to dehydration from gastrointestinal side effects Hypoglycemia : Particularly when combined with insulin or sulfonylureas Altering the prescribed dose through cutting or splitting makes it impossible for healthcare providers to accurately assess whether adverse effects are dose-related and how to appropriately adjust therapy

Regular activity accelerates fat loss and preserves muscle

While findings suggest a favorable therapeutic role and safety profile of GLP-1 RAs in managing overweight and obesity in IBD patients, limitations related to retrospective designs, small sample sizes, and potential risk of publication bias in most included studies underscore the need for larger prospective studies and randomized controlled trials
