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However, when both sygl-1 and lst-1 were removed, GLD-1(q361) protein increased dramatically in the distal germline ( Fig 6E ), with quantitation revealing a three-fold increase on average ( Fig 6F )

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Patients must maintain adequate fluid intake throughout treatment, which can be challenging when appetite and thirst signals are suppressed by medication

The findings will need to be replicated in the general population, although Corley was enthusiastic about the translational potential

Therefore, spacing doses appropriately can help mitigate these effects