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One small study found that about 78% of participants lost at least 5% of their body weight after 3 months, and many of the responders reported more regular cycles by 6 months

According to FDA prescribing information, approximately 20% of participants experience gastrointestinal side effects with either medication, while 60-75% of patients report at least one adverse event of any type

The greater weight loss we observed suggests that menopausal hormone therapy may be an important modifier of response to tirzepatide, pointing toward a more personalized approach, where menopausal status and menopausal hormone therapy use is considered when counseling midlife women and designing treatment plans, Hurtado Andrade detailed

Along these same lines, some experts have expressed concern that patients losing nearly 30% of their body weight could be dangerous