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As anticipated, among those patients who remained on treatment with semaglutide by the EOS, 78.2% and 78.9% of those in the low/no CKD risk cohort and CKD cohort, respectively, were being administered the full dose of 1 mg weekly at that time whereas only one patient remained with the initial dose of 0.25 mg weekly

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It became relatively quickly clear we need to combine several signals. Fast forward to 2003