semaglutide poster AAN 2026 Research shows semaglutide — commonly

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Yuma T, Tokuda M, Nishimoto N, Yokoi H, Izumori K

Teens with severe obesity who lost weight maintained more of their weight loss with use of a GLP-1 receptor agonist plus lifestyle therapy compared with lifestyle therapy alone, according to study findings published in Obesity

Since their introduction, GLP-1 medications have rapidly gained popularity for their effectiveness in helping people manage diabetes and obesity

Tirzepatide 15 mg led to higher discontinuation rate of study medication due to adverse events regardless of comparator, while all tirzepatide doses were safe in terms of serious adverse events and mortality

Studies with longer follow-up are needed to determine the durability, as weight regain after discontinuation of the medication is highly likely, and the high cost of these medications can limit their use