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Results A total of 28 trials with 23,622 participants (44.2% female) were included

Forecasting models often overestimate ROI: Many commercial forecasts fail to account for patient leakage, especially in obesity indications, leading to inflated expectations and missed market realities

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Key Point to Remember: MS = Young women, CNS demyelination, relapsing-remitting neurological deficits, MRI plaques, CSF oligoclonal bands, treated with steroids + disease-modifying agents.