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Clinical studies show that diabetic patients using dulaglutide lose around eight to 11 pounds of their body weight, while those without type 2 diabetes using semaglutide can achieve weight loss of 15 percent or more, especially at higher doses approved for weight management. The greater efficacy of semaglutide (Ozempic) makes it the preferred choice for patients focused on significant weight loss

Obesity is a complex disease with diverse patient populations characterized by metabolic differences, comorbidity status, compliance, and responsiveness to therapy

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Results Development of the secreted Exe4 peptide-coding gene To develop a one-shot in vivo genome editing-based therapy for DIO and pre-diabetes, we targeted the liver due to its large size and ease of transduction, anticipating effective therapeutic peptide/protein production and secretion following successful genome editing (Fig
