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Among the marketed large molecule injectable GLP-1 agonists, semaglutide, apart from weight-loss, is being studied for kidney disease and tirzepatide (a dual GLP-1 and GIP receptor agonist) is being evaluated for sleep apnea in Ph 3 clinical trials

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Treatment with 100uM Olaparib in nematodes exposed to high concentrations of glucose led to significant lifespan rescue

Interestingly, in the last years glucose lowering agents have been associated with a number of extra-glycemic effects, including cardiovascular benefits, nephroprotection, and weight loss

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