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however, trials developed mainly to evaluate the long-term impact of tirzepatide on cardiovascular events, including stroke, are currently in progress [42]

GLP-1 receptor agonists (GLP-1RA) have received extensive attention due to their advantages such as strong hypoglycemic effect, low risk of hypoglycemia (single agent), good weight loss effect and cardiovascular benefits

Those numbers surpass anything tirzepatide has demonstrated

In a large retrospective cohort study, GLP-1RAs significantly improve metabolic outcomes in individuals with MASLD, it can reduce major adverse cardiovascular events, all-cause mortality, and hospitalizations due to heart failure among individuals diagnosed with type 2 diabetes ( 2.3 Crosstalk between GLP-1 and and the gut microbiome 2.3.1 GLP-1 modulates the gut microbiota Emerging evidence indicates a bidirectional regulatory relationship between GLP-1RAs and the gut microbiota (Zhang et al., 2018

Common adverse reactions included nausea, diarrhea, and vomiting

247 The primary action often occurs through indirect mechanisms, such as insulin and somatostatin