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doi: 10.1111/dom.15292 [DOI] [PubMed] [Google Scholar] 52

Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase

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It also engages other intracellular pathways, including -arrestin-mediated MAPK signaling, where -arrestin desensitizes GPCRs by blocking G protein coupling and acts as a scaffold to activate mitogen-activated protein kinases (like ERK), promoting longer-term effects such as gene expression and cell survival by regulating gene transcription, independent of G protein signaling [22]

Inoue, K
