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About the author Eloise McLennan is the editor for pharmaphorums Deep Dive magazine

Semaglutide is an acylated GLP1 analog with a C18 fattydiacid side chain attached via a spacer at Lys26, promoting albumin binding and enzymatic stability

Tirzepatide adds GIP activity to that same pathway, which may give extra support for those who need a larger shift in body weight or who live with more complex metabolic issues

Specifically, patients must try empagliflozin and the maximally tolerated dose of metformin (if they can take it)

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