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Retatrutide is an investigational peptide known as LY3437943 that builds on the success of GLP-1 agonists like semaglutide and tirzepatide

Well, lets focus on that

Kurian, who is also the immediate past president of the American Society for Metabolic and Bariatric Surgery

It provides context for a provider conversation, not a clinical prediction

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Key risk factors include: Rapid weight loss: Losing weight quickly significantly increases gallstone risk Female sex: Women are two to three times more likely to develop gallstones than men Age over 40 years: Gallstone prevalence increases with age Obesity: Higher baseline BMI correlates with increased risk Previous history of gallstones: Prior biliary disease predicts recurrence Family history: Genetic factors contribute to gallstone susceptibility Certain ethnicities: Native American and Hispanic populations have higher baseline rates Estrogen exposure: Oral contraceptives, hormone replacement therapy, and multiple pregnancies Diabetes and dyslipidemia: Metabolic conditions affecting bile composition Prolonged fasting or TPN use: Reduces gallbladder contraction Patients should be educated about warning signs that may indicate gallstone complications