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Why GLP-1 (semaglutide or tirzepatide) Might Be Particularly Relevant in Older Adults Cardiometabolic protection Large cardiovascular outcome trials (e.g., SELECT , SUSTAIN-6 ) show semaglutide reduces major adverse cardiovascular events (MACE), and subgroup analyses suggest these benefits extend to older patients

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neuroimaging features (1) The most common finding is T2/FLAIR hyperintensity with strongly restricted diffusion affecting gyri in the parieto-occipital and temporal regions.(31589567) (2) Basal ganglia can be involved, which may be a poor prognostic sign.(31589567) (3) Characteristically, there is sparing of the thalami, white matter, and cerebellum

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