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glp 1 neuroinflammation A schematic representation of the potential role of brain GLP-1 Beyond diabetes and obesity: GLP‐1

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Endocrinology, Diabetes & Metabolism , 2 (3), e00068

glp 1 neuroinflammation A schematic representation of the potential role of brain GLP-1 Beyond diabetes and obesity: GLP1

Common side effectsnausea, vomiting, constipationare dose-dependent and often transient

glp 1 neuroinflammation A schematic representation of the potential role of brain GLP-1 Beyond diabetes and obesity: GLP1

Nucleic acids research 33 , 68846894, doi:10.1093/nar/gki1000 (2005)

glp 1 neuroinflammation A schematic representation of the potential role of brain GLP-1 Beyond diabetes and obesity: GLP1

NICE TA664 provides similar guidance for liraglutide 3 mg (Saxenda) in selected high-risk groups

glp 1 neuroinflammation A schematic representation of the potential role of brain GLP-1 Beyond diabetes and obesity: GLP1

It secretes inflammatory cytokines like interleukin-6 and tumor necrosis factor-alpha

glp 1 neuroinflammation A schematic representation of the potential role of brain GLP-1 Beyond diabetes and obesity: GLP1

Mechanistically, GLP1RAs have a beneficial effect on different stroke risk factors, support microvascular function, and reduce inflammation and oxidative stress

glp 1 neuroinflammation A schematic representation of the potential role of brain GLP-1 Beyond diabetes and obesity: GLP1

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