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Quick answer: Semaglutide, tirzepatide, and retatrutide are three peptides that look related on a slide yet differ substantially in the receptors they activate

Conjugates of particular antisense oligonucleotides to a GLP-1 analog enhanced the productive uptake of the oligonucleotide in GLP-1R expressing cells to elicit selective and effective gene silencing in vitro and in vivo with limited off-target accumulation of the oligonucleotide

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