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Accessed April 22, 2026.

More widespread use of SGLT2i in type 1 diabetes will necessitate implementation of strategies to assess and mitigate DKA risk, including preventative measures, patient education and continuous ketone monitoring, as well as a better understanding of the potential benefits for clinical cardiorenal outcomes, especially in high-risk populations such as people with CKD (Table 2) [46, 47]

In interviews with Calibrates chief executive Rob MacNaughton and Dr

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Williams, P.D

Whereas central nervous system (CNS) effects are determined by BBB penetration, ocular efficacy is governed by the traversal of the BRB